The Pathophysiology of Autism
نویسنده
چکیده
Autism has been classically defined by its behavioral symptoms. Traditional medical research has focused on genetic or intrinsic brain-based causes of autism. While both of these are important, additional research has focused on the underlying disordered biochemistry seen in many individuals with autism. Many of these biomedical factors are amenable to treatment. This article will review the main pathophysiologic factors seen in individuals with autism spectrum disorders.
منابع مشابه
Association of mtDNA mutation with Autism in Iranian patients
The autism spectrum disorders (ASD) are amongst the most heritable complex disorders. Although there have been many efforts to locate the genes associated with ASD risk, many has been remained to be disclosed about the genetics of ASD. Scrutiny's have only disclosed a small number of de novo and inherited variants significantly associated with susceptibility to ASD. These only comprise a small ...
متن کاملThe relationship between the cytokines and hs-CRP levels in children with autism and their comparison with healthy ones
Background: Previous studies suggest that dysregulation of the immune system is involved in the pathophysiology of autism spectrum disorders (ASD). The aim of the present study was to investigate some pre-and anti-inflammatory cytokines in the serum of children with autism and healthy children and to determine the correlation between these cytokines and hs-CRP. Materials and methods: Serum leve...
متن کاملThe Evaluation of Food Allergy on Behavior in Autistic Children
Background: Despite many efforts, the etiology of autism remains unknown. Food allergy has been suggested as a pathogenic factor in Autism Spectrum Disorder (ASD). Our aim in this study was to determine whether food allergy could be considered as a risk factor for autistic children. Methods: Thirty-nine autistic children were examined by the skin prick test (SPT), and total serum IgE was eva...
متن کاملHeterogeneity and convergence: the synaptic pathophysiology of autism.
Autism is a developmental disorder characterised by a high heterogeneity of clinical diagnoses and genetic associations. This heterogeneity is a challenge for the identification of the pathophysiology of the disease and for the development of new therapeutic strategies. New conceptual approaches are being used to try to challenge this complexity and gene cluster analysis studies suggest that th...
متن کاملOxidative stress in autism.
Autism is a severe developmental disorder with poorly understood etiology. Oxidative stress in autism has been studied at the membrane level and also by measuring products of lipid peroxidation, detoxifying agents (such as glutathione), and antioxidants involved in the defense system against reactive oxygen species (ROS). Lipid peroxidation markers are elevated in autism, indicating that oxidat...
متن کاملThe importance of autism research
This editorial discusses the importance of autism research, noting areas of progress and ongoing challenges and focusing on studies of the etiology, pathophysiology, and treatment of autism spectrum disorders.
متن کامل